Abstract
We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.
Keywords:
ESBL; France; Klebsiella pneumoniae; antimicrobial resistance; bacteria; chronic granulomatous disease; colistin; extended-spectrum β-lactamase; fungal meningitis; infection control; mcr-1; mcr-1 coliitin resistance; meningitis/encephalitis; multidrug resistance; polymyxin.
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Colistin / pharmacology*
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Drug Resistance, Bacterial*
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Drug Therapy, Combination
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France
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Genes, Bacterial
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Genome, Bacterial
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High-Throughput Nucleotide Sequencing
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Humans
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Klebsiella Infections / diagnosis
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Klebsiella Infections / drug therapy
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics
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Male
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Microbial Sensitivity Tests
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Plasmids / genetics
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Treatment Outcome
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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beta-Lactamases
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Colistin