mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France

Emerg Infect Dis. 2017 May;23(5):874-876. doi: 10.3201/eid2305.161942.

Abstract

We report intestinal carriage of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain with high-level resistance to colistin (MIC 24 mg/L) in a patient in France who had been hospitalized for fungal meningitis. The strain had the mcr-1 plasmid gene and an inactivated mgrB gene, which are associated with colistin resistance.

Keywords: ESBL; France; Klebsiella pneumoniae; antimicrobial resistance; bacteria; chronic granulomatous disease; colistin; extended-spectrum β-lactamase; fungal meningitis; infection control; mcr-1; mcr-1 coliitin resistance; meningitis/encephalitis; multidrug resistance; polymyxin.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Colistin / pharmacology*
  • Drug Resistance, Bacterial*
  • Drug Therapy, Combination
  • France
  • Genes, Bacterial
  • Genome, Bacterial
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Klebsiella Infections / diagnosis
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • Male
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Treatment Outcome
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • Colistin