Endomicroscopy is a new technique that allows human tissue to be characterized in vivo and in situ, circumventing the need for conventional biopsy and histology. Despite increased application and growing research interests in this area, the clinical application of endomicroscopy, however, is limited by difficulties in ergonomic control, consistent probe-tissue contact, large area surveillance, and retargeting. Recently, advances in high-speed imaging, mosaicing, and robotics have aimed to address these difficulties. The development of robot-assisted devices in particular has shown great promises in extending the clinical potential of endomicroscopy. Issues related to miniaturization, adaptation to tissue deformation, control stability, force and position compensation, cost, and sterility are being pursued by both research and commercial communities. In this review, recent clinical and technical developments in different aspects of computer and robotic assisted endomicroscopy interventions including instrumentation, multiscale integration, and high-speed imaging techniques are presented. We further address emerging trends and new research opportunities toward more widespread clinical acceptance of robotically assisted endomicroscopy technologies.