Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent

Dalong Ni; Jiawen Zhang; Jing Wang; Ping Hu; Yingying Jin; Zhongmin Tang; Zhenwei Yao; Wenbo Bu; Jianlin Shi

doi:10.1021/acsnano.7b01297

Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd³⁺-Doped Contrast Agent

ACS Nano. 2017 Apr 25;11(4):4256-4264. doi: 10.1021/acsnano.7b01297. Epub 2017 Mar 23.

Authors

Dalong Ni^{1

2

3}, Jiawen Zhang⁴, Jing Wang⁴, Ping Hu¹, Yingying Jin⁴, Zhongmin Tang^{1

2}, Zhenwei Yao⁴, Wenbo Bu^{1

3}, Jianlin Shi¹

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China.
² University of Chinese Academy of Science , Beijing 100049, China.
³ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , Shanghai 200062, China.
⁴ Department of Radiology, Huashan Hospital, Fudan University , Shanghai 200040, China.

PMID: 28323405
DOI: 10.1021/acsnano.7b01297

Abstract

Gd³⁺-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate the key parameters in order to obtain high-relaxivity CAs, according to the classic Solomon-Bloembergen-Morgen theory. Herein, a method of controlling oxygen vacancies in inorganic nanosized CAs has been developed for largely accelerated proton relaxation to obtain a high r₁ value. Such a strategy is verified on oxygen-deficient PEG-Na_xGdWO₃ nanorods, which exhibit a remarkable r₁ value up to 80 mM^-1 s^-1 (at 0.7 T) and a high r₁ value of 32.1 mM^-1 s^-1 on a clinical 3.0 T scanner, offering an excellent blood pool MRI performance at a low dose. Meanwhile, free electrons and/or oxygen-vacancy-induced small polarons can endow PEG-Na_xGdWO₃ nanorods with significant photothermal conversion for MRI-guided photothermal therapy.

Keywords: magnetic resonance imaging; oxygen vacancy; photothermal therapy; theranostic agent; tungsten bronzes.

Publication types

Research Support, Non-U.S. Gov't