Abstract
In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.
Keywords:
Angiogenesis; Dll4; Jagged 1; Nitric Oxide; Notch signalling pathway; Ovarian cancer; Polycystic ovary syndrome; VEGF.
MeSH terms
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Animals
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Female
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Gene Expression Regulation
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Humans
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Molecular Targeted Therapy
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Neovascularization, Pathologic / drug therapy
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Neovascularization, Pathologic / pathology
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Neovascularization, Physiologic* / drug effects
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Neovascularization, Physiologic* / genetics
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Ovary / blood supply*
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Ovary / drug effects
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Ovary / metabolism*
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Ovary / pathology
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Polycystic Ovary Syndrome / drug therapy
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Polycystic Ovary Syndrome / etiology
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Polycystic Ovary Syndrome / metabolism
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Polycystic Ovary Syndrome / pathology
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Receptors, Notch / chemistry
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Receptors, Notch / genetics
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Receptors, Notch / metabolism*
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Signal Transduction* / drug effects