Rescue of Cytokine Storm Due to HLH by Hemoadsorption in a CTLA4-Deficient Patient

Christine Greil; Fabian Roether; Paul La Rosée; Bodo Grimbacher; Daniel Duerschmied; Klaus Warnatz

doi:10.1007/s10875-017-0377-7

Rescue of Cytokine Storm Due to HLH by Hemoadsorption in a CTLA4-Deficient Patient

J Clin Immunol. 2017 Apr;37(3):273-276. doi: 10.1007/s10875-017-0377-7. Epub 2017 Mar 6.

Authors

Christine Greil¹, Fabian Roether², Paul La Rosée³, Bodo Grimbacher⁴, Daniel Duerschmied^{4

5}, Klaus Warnatz⁶

Affiliations

¹ Department of Hematology and Oncology, Medical Center, University of Freiburg, Freiburg, Germany.
² Department of Rheumatology and Clinical Immunology, Medical Center, University of Freiburg, Freiburg, Germany.
³ Klinik für Innere Medizin II, Schwarzwald-Baar-Klinikum, Villingen-Schwenningen, Germany.
⁴ Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Breisacher Str. 115, 79106, Freiburg, Germany.
⁵ University Heart Center Freiburg - Bad Krozingen and Interdisciplinary Medical Intensive Care, Medical Center, University of Freiburg, Freiburg, Germany.
⁶ Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Breisacher Str. 115, 79106, Freiburg, Germany. klaus.warnatz@uniklinik-freiburg.de.

PMID: 28265964
DOI: 10.1007/s10875-017-0377-7

No abstract available

Keywords: Abatacept; Cytotoxic T lymphocytic antigen-4 (CTLA-4) deficiency; EBV-associated Hodgkin lymphoma; Hemoadsorption; Hemophagocytic lymphohistiocytosis (HLH).

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Abatacept / therapeutic use*
Animals
CTLA-4 Antigen / genetics
CTLA-4 Antigen / metabolism*
Cytokines / metabolism*
Fever
Hematopoietic Stem Cell Transplantation
Hemodiafiltration / methods*
Humans
Immunomodulation
Inflammation Mediators / metabolism
Lymphohistiocytosis, Hemophagocytic / diagnosis*
Lymphohistiocytosis, Hemophagocytic / genetics
Male
Middle Aged
Molecular Targeted Therapy
Pedigree

Substances

CTLA-4 Antigen
Cytokines
Inflammation Mediators
Abatacept