Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data

J Med Virol. 2017 Aug;89(8):1494-1497. doi: 10.1002/jmv.24794. Epub 2017 Mar 14.

Abstract

Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction, and sputum) and lower (bronchoalveolar washings) respiratory tract of 110 children with CF. Air samples (n = 52) collected from the operating theatres and outpatient clinics were tested for RV. RV was found in 43% of children <5 years suffering an exacerbation, and 12% of older children (5-17 years). RV particles were detected in the air of clinic rooms. Detection of RV is important in better understanding viral infections in patients with CF.

Keywords: epidemiology; pathogenesis; respiratory tract; rhinovirus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Air Microbiology
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Picornaviridae Infections / epidemiology*
  • Picornaviridae Infections / virology
  • Polymerase Chain Reaction
  • RNA, Viral / analysis
  • RNA, Viral / genetics
  • Respiratory System / virology*
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / virology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rhinovirus / isolation & purification*

Substances

  • RNA, Viral