Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

Yanyan Tang; Jinpeng Wang; Yu Lian; Chunmei Fan; Ping Zhang; Yingfen Wu; Xiayu Li; Fang Xiong; Xiaoling Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng

doi:10.1186/s12943-017-0612-0

Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

Mol Cancer. 2017 Feb 17;16(1):42. doi: 10.1186/s12943-017-0612-0.

Authors

Yanyan Tang^{1

2

3}, Jinpeng Wang^{1

2}, Yu Lian^{1

2}, Chunmei Fan², Ping Zhang⁴, Yingfen Wu², Xiayu Li^{2

3}, Fang Xiong¹, Xiaoling Li^{1

2

3}, Guiyuan Li^{1

2

3}, Wei Xiong^{5

6

7}, Zhaoyang Zeng^{8

9

10}

Affiliations

¹ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ School of Information Science and Engineering, Central South University, Changsha, Hunan, China.
⁵ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁶ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁷ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁸ The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
⁹ The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.
¹⁰ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. zengzhaoyang@csu.edu.cn.

Abstract

Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports have shown that long non-coding RNAs (lncRNAs) are tightly associated with chromatin remodeling. In this review, we focused on important chromatin remodelers called the switching defective/sucrose nonfermenting (SWI/SNF) complexes, which use the energy of ATP hydrolysis to control gene transcription by altering chromatin structure. We summarize a link between lncRNAs and the SWI/SNF complexes and their role in chromatin remodeling and gene expression regulation in cancer, thereby providing systematic information and a better understanding of carcinogenesis.

Keywords: Carcinogenesis; Chromatin remodeling; Gene expression; Long non-coding RNAs (lncRNAs); The SWI/SNF complexes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
Chromatin Assembly and Disassembly*
Chromosomal Proteins, Non-Histone / metabolism*
Gene Expression Regulation, Neoplastic
Humans
Multiprotein Complexes / metabolism*
Neoplasms / genetics*
Neoplasms / metabolism*
Protein Binding
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism

Substances

Chromosomal Proteins, Non-Histone
Multiprotein Complexes
RNA, Long Noncoding