MSMB gene rs10993994 polymorphism increases the risk of prostate cancer

Oncotarget. 2017 Apr 25;8(17):28494-28501. doi: 10.18632/oncotarget.15312.

Abstract

Genome-wide association studies (GWASs) identified microseminoprotein-β (MSMB) gene rs10993994 polymorphism was significantly associated with prostate cancer (PC) risk. However, the association between MSMB gene rs10993994 polymorphism and PC risk remains controversial. Therefore, we performed a systematic review and meta-analysis by searching in the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. A total of 11 publications containing 13 case-control studies for rs10993994 polymorphism were included in our analysis. Our data indicated that MSMB gene rs10993994 polymorphism was associated with an increased risk of PC. Stratification analyses of ethnicity suggested rs10993994 polymorphism increased the risk of PC among Caucasians, but not among Asians. In conclusion, this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.

Keywords: MSMB; meta-analysis; prostate cancer; rs10993994; single nucleotide polymorphism.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Alleles*
  • Case-Control Studies
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Prostatic Neoplasms / genetics*
  • Prostatic Secretory Proteins / genetics*
  • Publication Bias

Substances

  • Prostatic Secretory Proteins
  • beta-microseminoprotein