Strategies for Targeted Therapy in Head and Neck Squamous Cell Carcinoma Using WEE1 Inhibitor AZD1775

JAMA Otolaryngol Head Neck Surg. 2017 Jun 1;143(6):631-633. doi: 10.1001/jamaoto.2016.4563.

Abstract

This study maps the cellular response to the WEE1 inhibitor and explores the contributions of p53 to its effect.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle / drug effects
  • Cell Cycle Proteins / antagonists & inhibitors*
  • Cell Line, Tumor
  • Enzyme Inhibitors / therapeutic use
  • Humans
  • Nuclear Proteins / antagonists & inhibitors*
  • Practice Guidelines as Topic*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Pyrazoles / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Pyrimidinones
  • Squamous Cell Carcinoma of Head and Neck / drug therapy*
  • Squamous Cell Carcinoma of Head and Neck / pathology

Substances

  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Nuclear Proteins
  • Pyrazoles
  • Pyrimidines
  • Pyrimidinones
  • Protein-Tyrosine Kinases
  • WEE1 protein, human
  • adavosertib