Aedes aegypti Larvicidal Sesquiterpene Alkaloids from Maytenus oblongata

J Nat Prod. 2017 Feb 24;80(2):384-390. doi: 10.1021/acs.jnatprod.6b00850. Epub 2017 Feb 10.

Abstract

Four new sesquiterpene alkaloids (1-4) with a β-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aedes / drug effects*
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Animals
  • French Guiana
  • Larva / drug effects*
  • Maytenus / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Stems / chemistry
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • 1,2-O-dibenzoyl-1,2-deacetyl-4-deoxyalatamine
  • 1-O-benzoyl-1-deacetyl-4-deoxyalatamine
  • 12,16-dihydroxyfriedelan-3-one
  • Alkaloids
  • Sesquiterpenes
  • Triterpenes