Satb1: Restraining PD1 and T Cell Exhaustion

Briana G Nixon; Ming O Li

doi:10.1016/j.immuni.2017.01.002

Satb1: Restraining PD1 and T Cell Exhaustion

Immunity. 2017 Jan 17;46(1):3-5. doi: 10.1016/j.immuni.2017.01.002.

Authors

Briana G Nixon¹, Ming O Li²

Affiliations

¹ Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: lim@mskcc.org.

PMID: 28099863
DOI: 10.1016/j.immuni.2017.01.002

Abstract

Mechanisms that govern PD1 expression and exhaustion in T cells are not fully understood. In this issue of Immunity, Stephen et al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promoting tumor immunity.

Publication types

Comment

MeSH terms

Genome
Humans
Matrix Attachment Region Binding Proteins / genetics*
T-Lymphocytes*

Substances

Matrix Attachment Region Binding Proteins