Effect of doxycycline and ursodeoxycholic acid on transthyretin amyloidosis

Amyloid. 2017 Mar;24(sup1):78-79. doi: 10.1080/13506129.2016.1269739. Epub 2016 Dec 31.
No abstract available

Publication types

  • Clinical Trial, Phase II
  • Letter

MeSH terms

  • Aged
  • Aged, 80 and over
  • Amyloid / antagonists & inhibitors
  • Amyloid / genetics
  • Amyloid / metabolism
  • Amyloid Neuropathies, Familial / drug therapy*
  • Amyloid Neuropathies, Familial / genetics
  • Amyloid Neuropathies, Familial / mortality
  • Amyloid Neuropathies, Familial / pathology
  • Biomarkers / blood
  • Cardiomyopathies / drug therapy*
  • Cardiomyopathies / genetics
  • Cardiomyopathies / mortality
  • Cardiomyopathies / pathology
  • Doxycycline / therapeutic use*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Gene Expression
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Natriuretic Peptide, Brain / blood
  • Patient Dropouts / statistics & numerical data
  • Peptide Fragments / blood
  • Prealbumin / genetics*
  • Prealbumin / metabolism
  • Prospective Studies
  • Survival Analysis
  • Treatment Failure
  • Ursodeoxycholic Acid / therapeutic use*

Substances

  • Amyloid
  • Biomarkers
  • Peptide Fragments
  • Prealbumin
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • Ursodeoxycholic Acid
  • Doxycycline

Supplementary concepts

  • Amyloidosis, Hereditary, Transthyretin-Related