sm"FISH"ing for Hedgehog

Michael L Drummond; Scott X Atwood

doi:10.1016/j.jid.2016.07.021

sm"FISH"ing for Hedgehog

J Invest Dermatol. 2017 Jan;137(1):13-15. doi: 10.1016/j.jid.2016.07.021.

Authors

Michael L Drummond¹, Scott X Atwood²

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA.
² Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA. Electronic address: satwood@uci.edu.

PMID: 28010757
DOI: 10.1016/j.jid.2016.07.021

Abstract

Patched (Ptch) receptors are critical negative regulators of Hedgehog signaling, where Ptch1 loss causes basal cell carcinoma and Ptch1;Ptch2 loss disrupts skin and hair follicle development. Adolphe et al. use single molecule fluorescent in situ hybridization to show quantitatively that Ptch receptors create a Hedgehog signaling gradient that may specify hair follicle development.

Publication types

Review
Comment

MeSH terms

Animals
Carcinoma, Squamous Cell / drug therapy
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology
Drug Resistance / genetics
Hair Diseases / genetics
Hair Diseases / pathology
Hair Follicle / growth & development
Hedgehog Proteins / genetics*
Humans
In Situ Hybridization, Fluorescence*
Patched Receptors / genetics*
Signal Transduction
Skin Neoplasms / drug therapy
Skin Neoplasms / genetics*
Skin Neoplasms / pathology

Substances

Hedgehog Proteins
Patched Receptors