Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

Petter Bjornstad; Richard J Johnson; Janet K Snell-Bergeon; Laura Pyle; Asa Davis; Nicole Foster; David Z Cherney; David M Maahs

doi:10.1016/j.jdiacomp.2016.11.015

Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank

J Diabetes Complications. 2017 Feb;31(2):387-389. doi: 10.1016/j.jdiacomp.2016.11.015. Epub 2016 Dec 7.

Authors

Petter Bjornstad¹, Richard J Johnson², Janet K Snell-Bergeon³, Laura Pyle⁴, Asa Davis⁵, Nicole Foster⁶, David Z Cherney⁷, David M Maahs⁸

Affiliations

¹ Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO; Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO. Electronic address: Petter.Bjornstad@childrenscolorado.org.
² Department of Nephrology, University of Colorado Denver, Aurora, CO.
³ Barbara Davis Center for Diabetes, University of Colorado Denver, Aurora, CO.
⁴ Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO.
⁵ Benaroya Research Institute, Seattle, WA.
⁶ Jaeb Center for Health Research Inc., Tampa, FL.
⁷ Department of Nephrology, University of Toronto School of Medicine, Toronto, ON.
⁸ Department of Pediatrics, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA.

Abstract

Vasopressin exerts important cardio-renal effects, but remains problematic to measure. Copeptin is a more stable peptide derived from the same precursor molecule. In this case-control study from the Type 1 Diabetes Exchange (T1DX) Biobank registry, men with T1D and albuminuria had greater copeptin concentrations than men with normoalbuminuria.

Keywords: Albuminuria; Copeptin; Diabetic kidney disease; Glomerular filtration rate; Type 1 diabetes.

MeSH terms

Adult
Aged
Albumins / analysis
Albuminuria / complications*
Albuminuria / epidemiology
Biomarkers / blood
Blood Banks
Case-Control Studies
Creatinine / urine
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / blood
Diabetes Mellitus, Type 1 / complications*
Diabetes Mellitus, Type 1 / urine
Glomerular Filtration Rate
Glycopeptides / blood*
Humans
Male
Middle Aged
Pilot Projects
Registries
Risk Factors
United States / epidemiology

Substances

Albumins
Biomarkers
Glycopeptides
copeptins
Creatinine

Grants and funding

T32 DK063687/DK/NIDDK NIH HHS/United States