A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings

Volkan Yesilyurt; Omid Veiseh; Joshua C Doloff; Jie Li; Suman Bose; Xi Xie; Andrew R Bader; Michael Chen; Matthew J Webber; Arturo J Vegas; Robert Langer; Daniel G Anderson

doi:10.1002/adhm.201601091

A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings

Adv Healthc Mater. 2017 Feb;6(4):10.1002/adhm.201601091. doi: 10.1002/adhm.201601091. Epub 2016 Dec 15.

Authors

Volkan Yesilyurt^{1

2}, Omid Veiseh^{1

3}, Joshua C Doloff^{1

2}, Jie Li^{1

2}, Suman Bose^{1

2}, Xi Xie¹, Andrew R Bader^{1

2}, Michael Chen^{1

2}, Matthew J Webber^{1

2}, Arturo J Vegas^{1

2}, Robert Langer^{1

2

3

4}, Daniel G Anderson^{1

2

3

4}

Affiliations

¹ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
² Department of Anesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
³ Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁴ Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Abstract

The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice.

Keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers.

MeSH terms

Animals
Catecholamines* / chemistry
Catecholamines* / pharmacology
Coated Materials, Biocompatible* / chemistry
Coated Materials, Biocompatible* / pharmacology
Drug Implants / chemistry
Drug Implants / pharmacology
Fibrosis
Foreign-Body Reaction / prevention & control
Membranes, Artificial*
Mice
Phosphorylcholine* / chemistry
Phosphorylcholine* / pharmacology

Substances

Catecholamines
Coated Materials, Biocompatible
Drug Implants
Membranes, Artificial
Phosphorylcholine

Abstract

MeSH terms

Substances

Grants and funding