An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Nahyun Kwon; Myoung Ki Cho; Sang Jun Park; Dayoung Kim; Sang-Jip Nam; Lei Cui; Hwan Myung Kim; Juyoung Yoon

doi:10.1039/c6cc08971b

An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Chem Commun (Camb). 2017 Jan 3;53(3):525-528. doi: 10.1039/c6cc08971b.

Authors

Nahyun Kwon¹, Myoung Ki Cho², Sang Jun Park², Dayoung Kim¹, Sang-Jip Nam¹, Lei Cui³, Hwan Myung Kim², Juyoung Yoon¹

Affiliations

¹ Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea. jyoon@ewha.ac.kr.
² Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea. kimhm@ajou.ac.kr.
³ Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea. jyoon@ewha.ac.kr and College of Science, University of Shanghai for Science and Technology, Shanghai, China. cuilei15@usst.edu.cn.

PMID: 27959364
DOI: 10.1039/c6cc08971b

Abstract

A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Fluorescent Dyes / chemistry*
Humans
Microscopy, Fluorescence, Multiphoton
NAD(P)H Dehydrogenase (Quinone) / analysis*
Optical Imaging
Propionates / chemistry*
Quinones / chemistry*

Substances

Fluorescent Dyes
Propionates
Quinones
NAD(P)H Dehydrogenase (Quinone)
NQO1 protein, human
propionic acid