HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

Wei Liu; Jun Ma; Yong Cheng; Hongbo Zhang; Wengguang Luo; Hongyan Zhang

doi:10.2147/BCTT.S119997

HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

Breast Cancer (Dove Med Press). 2016 Nov 24:8:223-229. doi: 10.2147/BCTT.S119997. eCollection 2016.

Authors

Wei Liu¹, Jun Ma¹, Yong Cheng¹, Hongbo Zhang¹, Wengguang Luo¹, Hongyan Zhang¹

Affiliation

¹ Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People's Republic of China.

Abstract

Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis and cancer progression. Hyaluronan-mediated motility receptor (HMMR) is an essential cancer-related gene in basal-like breast cancer (BLBC). In our study, HMMR antisense RNA 1 (HMMR-AS1) was analyzed in BLBC patients through polymerase chain reaction analysis. Here, we found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, the proliferation and migration abilities were remarkably suppressed via knocking down HMMR-AS1 (RP11-80G.1) in vitro. The results showed that lncRNA HMMR-AS1 (RP11-80G.1) influenced the progression of BLBCs through regulating HMMR, suggesting that HMMR-AS1 (RP11-80G.1) could be regarded as a novel biomarker and therapeutic target in the treatment of BLBCs in future.

Keywords: HMMR; HMMR antisense RNA 1; basal-like breast cancer cells; hyaluronan mediated motility receptor; long noncoding RNA.