AD Hyper-IgE Syndrome Due to a Novel Loss-of-Function Mutation in STAT3: a Diagnostic Pursuit Won by Clinical Acuity

Affiliations

• ¹ Laboratory Medicine, Experimental Laboratory Immunology, Department of Laboratory Medicine, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
• ² Department of Immunology and Microbiology, Childhood Immunology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
• ³ Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
• ⁴ St. Giles Laboratory of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
• ⁵ Department of Biochemistry, Laboratory of Biomolecular Modelling and Design, KU Leuven, Leuven, Belgium.
• ⁶ The Howard Hughes Medical Institute, New York, NY, USA.
• ⁷ The Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
• ⁸ The Imagine Institute, Paris Descartes University, Paris, France.
• ⁹ The Pediatric Hematology and Immunology Unit, Assistance Publique-Hôpitaux de Paris, Necker Hospital for Sick Children, Paris, France.
• ¹⁰ Paris Descartes University, Imagine Institute, Paris, France.
• ¹¹ Immunology Division, Garvan Institute of Medical Research, Darlinghurst, Australia.
• ¹² St Vincent's Clinical School, University of NSW Australia, Darlinghurst, Australia.
• ¹³ Department of Immunology and Microbiology, Childhood Immunology, University Hospitals Leuven and KU Leuven, Leuven, Belgium. Isabelle.Meyts@uzleuven.be.
• ¹⁴ Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. Isabelle.Meyts@uzleuven.be.