Gal3 Links Inflammation and Insulin Resistance

Marie Siwicki; Camilla Engblom; Mikael J Pittet

doi:10.1016/j.cmet.2016.10.014

Gal3 Links Inflammation and Insulin Resistance

Cell Metab. 2016 Nov 8;24(5):655-656. doi: 10.1016/j.cmet.2016.10.014.

Authors

Marie Siwicki¹, Camilla Engblom¹, Mikael J Pittet²

Affiliations

¹ Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
² Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address: mpittet@mgh.harvard.edu.

PMID: 27829136
DOI: 10.1016/j.cmet.2016.10.014

Abstract

The connection between obesity-induced insulin resistance and inflammation is established, but targeting inflammatory mediators like TNF-α and IL-1β have had limited success improving insulin sensitivity in patients. Now, Li et al. (2016) indicate that galectin-3 could be a targetable link between inflammation and insulin sensitivity.

Publication types

Comment

MeSH terms

Humans
Inflammation
Inflammation Mediators
Insulin Resistance*
Insulin*
Obesity
Tumor Necrosis Factor-alpha

Substances

Inflammation Mediators
Insulin
Tumor Necrosis Factor-alpha

Grants and funding

R01 AI084880/AI/NIAID NIH HHS/United States