Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections

H Ottosson; F Nylén; P Sarker; E Miraglia; P Bergman; G H Gudmundsson; R Raqib; B Agerberth; R Strömberg

doi:10.1038/srep36692

Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections

Sci Rep. 2016 Nov 9:6:36692. doi: 10.1038/srep36692.

Authors

H Ottosson¹, F Nylén², P Sarker³, E Miraglia², P Bergman², G H Gudmundsson⁴, R Raqib³, B Agerberth², R Strömberg¹

Affiliations

¹ Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
² Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
³ International Center for Diarrheal Disease Research, Bangladesh (icddr, b) Dhaka, Bangladesh.
⁴ Biomedical Center, University of Iceland, Reykjavik, Iceland.

Abstract

A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Antimicrobial Cationic Peptides / metabolism*
Cathelicidins
Cell Line
Dysentery, Bacillary / drug therapy*
Female
Humans
Male
Phenylenediamines / chemical synthesis
Phenylenediamines / chemistry
Phenylenediamines / pharmacology*
Rabbits

Substances

Antimicrobial Cationic Peptides
Phenylenediamines
Cathelicidins