Research Advances in the Mutation of TET2 Gene in Myeloid Maligancies

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2016 Oct 10;38(5):583-588. doi: 10.3881/j.issn.1000-503X.2016.05.017.

Abstract

TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review,the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

Publication types

  • Review

MeSH terms

  • 5-Methylcytosine / analogs & derivatives
  • 5-Methylcytosine / metabolism
  • DNA-Binding Proteins / genetics*
  • Dioxygenases
  • Hematologic Neoplasms / genetics*
  • Humans
  • Mutation
  • Proto-Oncogene Proteins / genetics*

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • 5-hydroxymethylcytosine
  • 5-Methylcytosine
  • Dioxygenases
  • TET2 protein, human