The Bionic Eye: A Quarter Century of Retinal Prosthesis Research and Development

Mark S Humayun; Eugene de Juan Jr; Gislin Dagnelie

doi:10.1016/j.ophtha.2016.06.044

The Bionic Eye: A Quarter Century of Retinal Prosthesis Research and Development

Ophthalmology. 2016 Oct;123(10S):S89-S97. doi: 10.1016/j.ophtha.2016.06.044.

Authors

Mark S Humayun¹, Eugene de Juan Jr², Gislin Dagnelie³

Affiliations

¹ USC Roski Eye Institute and USC Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, California.
² ForSight Labs, Menlo Park, California.
³ Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: gdagnelie@jhmi.edu.

PMID: 27664290
DOI: 10.1016/j.ophtha.2016.06.044

Abstract

This article describes the history of visual prostheses, with emphasis on the development of the Argus II retinal prosthesis system (Second Sight Medical Products, Inc., Sylmar, CA). A brief overview of cortical electrical stimulation in the blind is provided, followed by an account of the design and development of retinal stimulation equipment at the Duke Eye Center in the late 1980s; the first human intraoperative tests there and the subsequent 8 years of tests at the Wilmer Eye Institute; the transfer of the project to the Doheny Eye Institute at the University of Southern California and the founding of Second Sight Medical Products; and the development and clinical trials of the Argus I and Argus II systems. In a series of vignettes, we pay tribute to the many colleagues and patient volunteers without whose help the work would not have been possible.