Current and Upcoming Therapies for Ocular Surface Chemical Injuries

Ocul Surf. 2017 Jan;15(1):48-64. doi: 10.1016/j.jtos.2016.09.002. Epub 2016 Sep 17.

Abstract

Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries.

Keywords: chemical burn; cornea; limbal stem cell deficiency; ocular chemical burn; ocular surface; stem cell.

Publication types

  • Review

MeSH terms

  • Burns, Chemical
  • Eye Injuries*
  • Humans
  • Limbus Corneae
  • Stem Cell Transplantation
  • Treatment Outcome