[Prolonged response with paclitaxel after immunotherapy by pembrolizumab in lung cancer]

Abstract

Introduction: Pembrolizumab, a humanized monoclonal antibody IgG4 anti-PD-1, having offered promising results in patients suffering from non-small cell lung cancer metastatic and heavily pretreated.

Observation: We report here the case of an unexpected good response after pembrolizumab failure obtained with paclitaxel in a 68-year-old patient with stage IV lung adenocarcinoma. Moreover, the response duration with paclitaxel was more than fourteen months.

Conclusion: Our case suggests a mutual potentiation of chemotherapy and immunotherapy, and raises the issue of the treatment sequence to favor.

Keywords: Advanced non-small-cell lung cancer; Cancer bronchique non à petites cellules avancé; Checkpoint inhibitors; Immunotherapy; Immunothérapie; Inhibiteurs des points de contrôle immunologiques; Pembrolizumab.