Functional Antibodies and Protection against Blood-stage Malaria

Andrew Teo; Gaoqian Feng; Graham V Brown; James G Beeson; Stephen J Rogerson

doi:10.1016/j.pt.2016.07.003

Functional Antibodies and Protection against Blood-stage Malaria

Trends Parasitol. 2016 Nov;32(11):887-898. doi: 10.1016/j.pt.2016.07.003. Epub 2016 Aug 18.

Authors

Andrew Teo¹, Gaoqian Feng², Graham V Brown³, James G Beeson⁴, Stephen J Rogerson⁵

Affiliations

¹ Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
² Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Australia.
³ Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Victorian Infectious Diseases Service, Doherty Institute for Infection and Immunity, Melbourne, Australia.
⁴ Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Australia; Department of Microbiology, Monash University, Melbourne, Victoria, Australia.
⁵ Department of Medicine, University of Melbourne (Royal Melbourne Hospital), Parkville, Australia; Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Victorian Infectious Diseases Service, Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: sroger@unimelb.edu.au.

PMID: 27546781
DOI: 10.1016/j.pt.2016.07.003

Abstract

Numerous efforts to understand the functional roles of antibodies demonstrated that they can protect against malaria. However, it is unclear which antibody responses are the best correlates of immunity, and which antibody functions are most important in protection from disease. Understanding the role of antibodies in protection against malaria is crucial for antimalarial vaccine design. In this review, the specific functional properties of naturally acquired and vaccine-induced antibodies that correlate to protection from the blood stages of Plasmodium falciparum malaria are re-examined and the gaps in knowledge related to antibody function in malarial immunity are highlighted.

Keywords: Plasmodium falciparum; antibody; immunity; naturally acquired; vaccine design.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Protozoan / blood*
Antibodies, Protozoan / immunology*
Antigens, Protozoan / immunology
Humans
Immunity*
Malaria Vaccines / immunology*
Malaria, Falciparum / immunology*
Malaria, Falciparum / prevention & control*
Plasmodium falciparum / immunology

Substances

Antibodies, Protozoan
Antigens, Protozoan
Malaria Vaccines