Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum

Genome Res. 2016 Sep;26(9):1288-99. doi: 10.1101/gr.203711.115. Epub 2016 Aug 16.

Abstract

The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is either highly repetitive or highly variable and thus difficult to analyze using short-read sequencing technologies. Here, we describe a resource of deep sequencing data on parents and progeny from genetic crosses, which has enabled us to perform the first genome-wide, integrated analysis of SNP, indel and complex polymorphisms, using Mendelian error rates as an indicator of genotypic accuracy. These data reveal that indels are exceptionally abundant, being more common than SNPs and thus the dominant mode of polymorphism within the core genome. We use the high density of SNP and indel markers to analyze patterns of meiotic recombination, confirming a high rate of crossover events and providing the first estimates for the rate of non-crossover events and the length of conversion tracts. We observe several instances of meiotic recombination within copy number variants associated with drug resistance, demonstrating a mechanism whereby fitness costs associated with resistance mutations could be compensated and greater phenotypic plasticity could be acquired.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • DNA Copy Number Variations / genetics
  • Drug Resistance / genetics*
  • Genetic Variation*
  • Genome, Protozoan / genetics
  • High-Throughput Nucleotide Sequencing
  • Humans
  • INDEL Mutation
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / genetics*
  • Malaria, Falciparum / parasitology
  • Meiosis / genetics
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / genetics*
  • Plasmodium falciparum / pathogenicity
  • Polymorphism, Single Nucleotide
  • Recombination, Genetic / genetics