Pre-Metastatic Niche Formation Has Taken Its TOLL

Candia M Kenific; Laura Nogués; David Lyden

doi:10.1016/j.ccell.2016.07.012

Pre-Metastatic Niche Formation Has Taken Its TOLL

Cancer Cell. 2016 Aug 8;30(2):189-191. doi: 10.1016/j.ccell.2016.07.012.

Authors

Candia M Kenific¹, Laura Nogués¹, David Lyden²

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
² Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: dcl2001@med.cornell.edu.

PMID: 27505667
DOI: 10.1016/j.ccell.2016.07.012

Abstract

Pre-Metastatic Niches (PMNs) result from communications between primary tumors and the microenvironment of future distant metastasis via tumor-derived factors. In this issue of Cancer Cell, Liu et al. show that TLR3 activation in lung epithelial cells by tumor exosomal RNAs triggers neutrophil recruitment, which contributes to PMN formation and metastasis.

Publication types

Comment

MeSH terms

Epithelial Cells
Humans
Lung
Neoplasm Metastasis
Neoplasms*
RNA, Neoplasm
Tumor Microenvironment*

Substances

RNA, Neoplasm