Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury

Hui Liu; Qian Li; Ying Wang; Huimin Hong; Mengting Chen; Yingyi Wang; Fenfang Hong; Shulong Yang

doi:10.1111/hepr.12783

Elevated nitric oxide levels associated with hepatic cell apoptosis during liver injury

Hepatol Res. 2017 Feb;47(2):178-185. doi: 10.1111/hepr.12783. Epub 2016 Sep 5.

Authors

Hui Liu¹, Qian Li¹, Ying Wang¹, Huimin Hong¹, Mengting Chen¹, Yingyi Wang¹, Fenfang Hong², Shulong Yang¹

Affiliations

¹ Department of Physiology, College of Medicine, Nanchang University, Nanchang, China.
² Department of Experimental Teaching, Nanchang University, Nanchang, China.

PMID: 27489194
DOI: 10.1111/hepr.12783

Abstract

Hepatic injury is a major event in liver surgery such as liver transplantation and it always leads to hepatic cell apoptosis. Nitric oxide (NO) is a key signaling regulation molecule. Many researchers have shown that increased NO level can influence liver cell apoptosis by promoting or inhibiting the relative signaling pathways that are involved in the caspase family, Bax/Bcl-2, mitochondria, oxidative stress, death receptors, and mitogen-activated protein kinases. Elucidating the relationships between NO and hepatic cell apoptosis is necessary for ameliorating prognosis of liver surgery. This article reviews the newest research progress in the relationships between higher NO levels and hepatic cell apoptosis in liver injury.

Keywords: apoptosis; hepatic injury; liver cell; nitric oxide.

Publication types

Review