Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery

Adv Healthc Mater. 2016 Oct;5(19):2493-2499. doi: 10.1002/adhm.201600470. Epub 2016 Jul 27.

Abstract

A simultaneously photo-cleavable and activatable prodrug-backboned block copolymer (BCP) micelle strategy is demonstrated. Without light treatment, the micelles stay silent and inactivated, being biocompatible to normal tissues. Concurrent chain cleavage of BCP micelles and the activation of Pt(IV) prodrug could be temporally and spatially triggered by UV or even visible light for precise anticancer drug delivery.

Keywords: controlled and precise drug delivery; photo-activatability; photo-cleavability; platinum; prodrug-backboned block copolymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry*
  • Drug Delivery Systems / methods
  • Female
  • HeLa Cells
  • Humans
  • Light
  • Mice
  • Mice, Inbred BALB C
  • Micelles
  • Polymers / chemistry*
  • Prodrugs / administration & dosage*
  • Prodrugs / chemistry*

Substances

  • Antineoplastic Agents
  • Micelles
  • Polymers
  • Prodrugs