Association of TLR polymorphisms with bronchopulmonary dysplasia

Amr Hosny Malash; Aliaa Adel Ali; Rania Mohamed Samy; Radwa Ahmed Shamma

doi:10.1016/j.gene.2016.07.049

Association of TLR polymorphisms with bronchopulmonary dysplasia

Gene. 2016 Oct 30;592(1):23-28. doi: 10.1016/j.gene.2016.07.049. Epub 2016 Jul 25.

Authors

Amr Hosny Malash¹, Aliaa Adel Ali², Rania Mohamed Samy³, Radwa Ahmed Shamma⁴

Affiliations

¹ Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: malash5@yahoo.com.
² Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: draliaaadel@yahoo.com.
³ Clinical Pathology, Faculty of Medicine, Cairo University, Egypt. Electronic address: rania_sami1976@yahoo.com.
⁴ Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: radwa.shamma@hotmail.com.

PMID: 27457283
DOI: 10.1016/j.gene.2016.07.049

Abstract

Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia.

Keywords: Bronchopulmonary dysplasia; Neonatal mortality; Oxygen therapy; Preterm neonates; Sepsis; Toll-like receptors.

MeSH terms

Bronchopulmonary Dysplasia / genetics*
Bronchopulmonary Dysplasia / pathology
Case-Control Studies
Female
Humans
Infant, Newborn
Infant, Premature
Male
Membrane Glycoproteins / genetics*
Polymorphism, Single Nucleotide*
Receptors, Interleukin-1 / genetics*
Toll-Like Receptor 5 / genetics*

Substances

Membrane Glycoproteins
Receptors, Interleukin-1
TIRAP protein, human
TLR5 protein, human
Toll-Like Receptor 5