Effects of renal denervation on heart failure biomarkers and blood pressure in patients with resistant hypertension

Biomark Med. 2016 Aug;10(8):841-51. doi: 10.2217/bmm-2016-0098.

Abstract

Aim: This multicenter study investigated the effect of renal denervation therapy (RDN) on the heart failure related biomarkers NT-proBNP, ST-2, galectin-3 and hs-TnI.

Patients & methods: We included 157 patients with resistant hypertension undergoing RDN. Blood sampling was performed before and 6 months after RDN.

Results: Six months after RDN systolic blood pressure (BP) was reduced by 24 mmHg. Biomarker concentrations were not changed after RDN, except a small increase of hs-TnI by 0.3 pg/ml. In individuals with high baseline BP, we observed a BP reduction of 45 mmHg and a decrease of hs-TnI concentrations by 1.2 pg/ml.

Conclusion: In this multicenter analysis RDN did significantly reduce systolic BP. However, NT-proBNP, ST-2, galectin-3 and hs-TnI did not correspond to BP reduction 6 months after RDN.

Keywords: NT-proBNP; biomarker; hypertension; renal denervation; responder; troponin I.

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Blood Pressure / physiology*
  • Echocardiography
  • Female
  • Galectin 3 / blood
  • Heart Failure / complications
  • Heart Failure / diagnosis*
  • Humans
  • Hypertension / complications*
  • Hypertrophy, Left Ventricular / diagnostic imaging
  • Interleukin-1 Receptor-Like 1 Protein / blood
  • Kidney / innervation*
  • Kidney / physiopathology
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood
  • Peptide Fragments / blood
  • Pulse Wave Analysis
  • Troponin I / blood

Substances

  • Biomarkers
  • Galectin 3
  • IL1RL1 protein, human
  • Interleukin-1 Receptor-Like 1 Protein
  • Peptide Fragments
  • Troponin I
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain