Low-carbohydrate diet combined with SGLT2 inhibitor for refractory hyperglycemia caused by insulin antibodies

Riyoko Shigeno; Ichiro Horie; Takao Ando; Norio Abiru; Atsushi Kawakami

doi:10.1016/j.diabres.2016.04.032

Low-carbohydrate diet combined with SGLT2 inhibitor for refractory hyperglycemia caused by insulin antibodies

Diabetes Res Clin Pract. 2016 Jun:116:43-5. doi: 10.1016/j.diabres.2016.04.032. Epub 2016 Apr 26.

Authors

Riyoko Shigeno¹, Ichiro Horie², Takao Ando³, Norio Abiru⁴, Atsushi Kawakami⁵

Affiliations

¹ Department of Endocrinology and Metabolism, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: a205mm038s@yahoo.co.jp.
² Department of Endocrinology and Metabolism, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: holy197741@me.com.
³ Department of Endocrinology and Metabolism, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: takaoando@gmail.com.
⁴ Department of Endocrinology and Metabolism, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: abirun@nagasaki-u.ac.jp.
⁵ Department of Endocrinology and Metabolism, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Electronic address: atsushik@nagasaki-u.ac.jp.

PMID: 27321315
DOI: 10.1016/j.diabres.2016.04.032

Abstract

A low-carbohydrate diet is effective to improve hyperglycemia via insulin-independent actions. We report here that a low-carbohydrate diet combined with an SGLT2 inhibitor was effective and safe to treat refractory hyperglycemia in the perioperative period in a type 2 diabetes patient complicated with a high titer of insulin antibodies.

Keywords: Insulin antibodies; Insulin autoimmune syndrome; Low-carbohydrate diet; SGLT2; Scatchard analysis.

Publication types

Case Reports

MeSH terms

Adamantane / analogs & derivatives
Adamantane / therapeutic use
Aged
Benzhydryl Compounds / therapeutic use*
Blood Glucose / drug effects
C-Peptide / blood
Diabetes Mellitus, Type 2 / immunology
Diabetes Mellitus, Type 2 / therapy*
Diet, Carbohydrate-Restricted / methods*
Drug Therapy, Combination
Glucosides / therapeutic use*
Humans
Hypoglycemic Agents / therapeutic use*
Insulin / blood
Insulin Antibodies / immunology
Insulin Resistance / immunology*
Male
Metformin / therapeutic use
Nitriles / therapeutic use
Pyrrolidines / therapeutic use
Sodium-Glucose Transporter 2 Inhibitors*
Vildagliptin

Substances

Benzhydryl Compounds
Blood Glucose
C-Peptide
Glucosides
Hypoglycemic Agents
Insulin
Insulin Antibodies
Nitriles
Pyrrolidines
Sodium-Glucose Transporter 2 Inhibitors
dapagliflozin
Metformin
Vildagliptin
Adamantane