A Six-Stage Workflow for Robust Application of Systems Pharmacology

K Gadkar; D C Kirouac; D E Mager; P H van der Graaf; S Ramanujan

doi:10.1002/psp4.12071

A Six-Stage Workflow for Robust Application of Systems Pharmacology

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16.

Authors

K Gadkar¹, D C Kirouac¹, D E Mager², P H van der Graaf^{3

4}, S Ramanujan¹

Affiliations

¹ Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.
² Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.
³ Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
⁴ Certara QSP, Canterbury, UK.

Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

MeSH terms

Computational Biology / methods*
Database Management Systems*
Humans
Pharmacology, Clinical / methods*
Systems Biology / methods*
Workflow*