HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Özgür Yaldizli; Varun Sethi; Matteo Pardini; Carmen Tur; Kin Y Mok; Nils Muhlert; Zheng Liu; Rebecca S Samson; Claudia A M Wheeler-Kingshott; Tarek A Yousry; Henry Houlden; John Hardy; David H Miller; Declan T Chard

doi:10.1016/j.msard.2016.03.003

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Mult Scler Relat Disord. 2016 May:7:47-52. doi: 10.1016/j.msard.2016.03.003. Epub 2016 Mar 7.

Authors

Affiliations

¹ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neurology, University Hospital Basel, Basel, Switzerland. Electronic address: o.yaldizli@ucl.ac.uk.
² Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK.
³ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
⁴ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; MS Centre of Catalonia (Cemcat), Neurology-Neuroimmunology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
⁵ Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Division of Life Science, Hong Kong University of Science and Technology, Hong Kong SAR, China.
⁶ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK; School of Psychological Sciences, University of Manchester, Manchester, UK.
⁷ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
⁸ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK; Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.
⁹ Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
¹⁰ Queen Square MS Centre NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK.

PMID: 27237756
DOI: 10.1016/j.msard.2016.03.003

Abstract

Background: The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology.

Aim: To assess HLA-DRB(*)1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology.

Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB(*)1501 haplotype was determined by genotyping (rs3135388).

Results: No significant differences were observed in MRI measures between the HLA-DRB(*)1501 subgroups.

Conclusions: The HLA-DRB(*)1501 haplotype is not strongly associated with MRI-visible grey matter pathology.

Keywords: Cortical lesion; Grey matter; HLA-DRB*1501; Magnetization transfer ratio; Multiple sclerosis.

MeSH terms

Adult
Cerebral Cortex / diagnostic imaging*
Disability Evaluation
Female
Genetic Predisposition to Disease
Genotype
Gray Matter / diagnostic imaging*
HLA-DRB1 Chains / genetics*
Haplotypes
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / diagnostic imaging*
Multiple Sclerosis / genetics*
Organ Size
Polymorphism, Single Nucleotide
Young Adult

Substances

HLA-DRB1 Chains
HLA-DRB1*15:01 antigen

Abstract

MeSH terms

Substances

Grants and funding