Fishing for Function in the Human Gene Pool

Iros Barozzi; Axel Visel; Diane E Dickel

doi:10.1016/j.tig.2016.05.002

Fishing for Function in the Human Gene Pool

Trends Genet. 2016 Jul;32(7):392-394. doi: 10.1016/j.tig.2016.05.002. Epub 2016 May 21.

Authors

Iros Barozzi¹, Axel Visel², Diane E Dickel³

Affiliations

¹ Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
² Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA; School of Natural Sciences, University of California, Merced, California, USA. Electronic address: avisel@lbl.gov.
³ Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: dedickel@lbl.gov.

Abstract

Identification and characterization of causal non-coding variants in human genomes is challenging and requires substantial experimental resources. A new study by Tehranchi et al. describes a cost-effective approach for accurate mapping of molecular quantitative trait loci (QTLs) from pooled samples, a powerful way to link disease-associated changes to molecular functions.

Keywords: GWAS; QTL; cis-regulation; non-coding DNA.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Chromosome Mapping
Gene Pool
Genetic Diseases, Inborn / genetics*
Genetic Variation
Genome, Human*
Humans
Polymorphism, Single Nucleotide / genetics
Quantitative Trait Loci / genetics*
Regulatory Sequences, Nucleic Acid / genetics*

Abstract

Publication types

MeSH terms

Grants and funding