Inflammatory Myofibroblastic Tumors: Current Update

Venkateswar R Surabhi; Steven Chua; Rajan P Patel; Naoki Takahashi; Neeraj Lalwani; Srinivasa R Prasad

doi:10.1016/j.rcl.2015.12.005

Inflammatory Myofibroblastic Tumors: Current Update

Radiol Clin North Am. 2016 May;54(3):553-63. doi: 10.1016/j.rcl.2015.12.005. Epub 2016 Mar 12.

Authors

Venkateswar R Surabhi¹, Steven Chua², Rajan P Patel², Naoki Takahashi³, Neeraj Lalwani⁴, Srinivasa R Prasad⁵

Affiliations

¹ Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 2.130, Houston, TX 77030, USA. Electronic address: Venkateswar.R.Surabhi@uth.tmc.edu.
² Department of Diagnostic and Interventional Imaging, The University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 2.130, Houston, TX 77030, USA.
³ Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
⁴ Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-7117, USA.
⁵ Department of Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1473, Houston, TX 77030, USA.

PMID: 27153788
DOI: 10.1016/j.rcl.2015.12.005

Abstract

Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of uncertain histogenesis with a variable inflammatory component. IMTs show characteristic fasciitis-like, compact spindle cell and hypocellular fibrous histologic patterns and distinctive molecular features. Imaging findings reflect pathologic features and vary from an ill-defined, infiltrating lesion to a wellcircumscribed, soft tissue mass owing to variable inflammatory, stromal, and myofibroblastic components.

Keywords: Imaging findings; Inflammatory myofibroblastic tumors; Inflammatory pseudotumor; Local recurrence; Mesenchymal neoplasms.

Publication types

Review

MeSH terms

Abdominal Neoplasms / diagnostic imaging*
Diagnosis, Differential
Evidence-Based Medicine
Granuloma, Plasma Cell / diagnostic imaging*
Humans
Lung Neoplasms / diagnostic imaging*
Magnetic Resonance Imaging / methods
Myofibroma / diagnostic imaging*
Pelvic Neoplasms / diagnostic imaging*
Tomography, X-Ray Computed / methods