Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015

Wen Ling Wang; Hui Juan Wang; Yao Deng; Tie Song; Jia Ming Lan; Gui Zhen Wu; Chang Wen Ke; Wen Jie Tan

doi:10.3967/bes2016.027

Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015

Biomed Environ Sci. 2016 Mar;29(3):219-23. doi: 10.3967/bes2016.027.

Authors

Wen Ling Wang¹, Hui Juan Wang¹, Yao Deng¹, Tie Song², Jia Ming Lan¹, Gui Zhen Wu¹, Chang Wen Ke², Wen Jie Tan¹

Affiliations

¹ Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
² Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.

Abstract

The first imported Middle East respiratory syndrome (MERS) case in China was identified in May 2015. We determined the kinetics of antibody (IgG and IgM) and neutralizing antibodies against MERS-coronavirus (MERS-CoV) in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay (ELISA) of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / blood
Antibodies, Viral / blood
China / epidemiology
Contact Tracing
Coronavirus Infections / blood
Coronavirus Infections / epidemiology*
Coronavirus Infections / transmission*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Male
Republic of Korea / epidemiology
Travel*

Substances

Antibodies, Neutralizing
Antibodies, Viral
Immunoglobulin G
Immunoglobulin M