Transfusion reactions: prevention, diagnosis, and treatment

Meghan Delaney; Silvano Wendel; Rachel S Bercovitz; Joan Cid; Claudia Cohn; Nancy M Dunbar; Torunn O Apelseth; Mark Popovsky; Simon J Stanworth; Alan Tinmouth; Leo Van De Watering; Jonathan H Waters; Mark Yazer; Alyssa Ziman; Biomedical Excellence for Safer Transfusion (BEST) Collaborative

doi:10.1016/S0140-6736(15)01313-6

Transfusion reactions: prevention, diagnosis, and treatment

Lancet. 2016 Dec 3;388(10061):2825-2836. doi: 10.1016/S0140-6736(15)01313-6. Epub 2016 Apr 12.

Authors

Affiliations

¹ Bloodworks NW, Seattle, WA, USA; University of Washington, Department of Laboratory Medicine, Seattle, WA, USA. Electronic address: meghand@bloodworksnw.org.
² Hospital Sirio Libanes Blood Bank, Sao Paulo, Brazil.
³ BloodCenter of Wisconsin, Milwaukee, WI, USA.
⁴ Department of Hemotherapy and Hemostasis, CDB, IDIBAPS, Hospital Clínic, UB, Barcelona, Spain.
⁵ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
⁶ Department of Pathology and Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
⁷ Laboratory of Clinical Biochemistry and Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.
⁸ Haemonetics Corporation, Braintree, MA, USA.
⁹ NHS Blood and Transplant/Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
¹⁰ Department of Medicine and Department of Laboratory Medicine & Pathology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Centre for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
¹¹ Center for Clinical Transfusion Research, Sanquin, Netherlands.
¹² Department of Anesthesiology & Bioengineering, University of Pittsburgh & McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA.
¹³ Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh, Institute for Transfusion Medicine, Pittsburgh, PA, USA.
¹⁴ Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

PMID: 27083327
DOI: 10.1016/S0140-6736(15)01313-6

Abstract

Blood transfusion is one of the most common procedures in patients in hospital so it is imperative that clinicians are knowledgeable about appropriate blood product administration, as well as the signs, symptoms, and management of transfusion reactions. In this Review, we, an international panel, provide a synopsis of the pathophysiology, treatment, and management of each diagnostic category of transfusion reaction using evidence-based recommendations whenever available.

Publication types

Review

MeSH terms

Blood Transfusion / methods*
Blood Transfusion / standards
Evidence-Based Medicine
Humans
Transfusion Reaction / diagnosis*
Transfusion Reaction / physiopathology
Transfusion Reaction / prevention & control*
Transfusion Reaction / therapy*