Identification of novel exonic mobile element insertions in epithelial ovarian cancers

Takahide Hayano; Shiro Yamada; Kazuyoshi Hosomichi; Hirofumi Nakaoka; Kosuke Yoshihara; Sosuke Adachi; Katsunori Kashima; Kenichi Tanaka; Takayuki Enomoto; Ituro Inoue

doi:10.1038/hgv.2015.30

Identification of novel exonic mobile element insertions in epithelial ovarian cancers

Hum Genome Var. 2015 Oct 1:2:15030. doi: 10.1038/hgv.2015.30. eCollection 2015.

Affiliations

¹ Division of Human Genetics, National Institute of Genetics , Mishima, Japan.
² Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences , Niigata, Japan.
³ Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Niigata Medical Center Hospital, Niigata, Japan.

Abstract

Mobile elements comprise about half of the human genome. Three active mobile element families (L1, Alu, and SVA) possibly cause diseases such as cancer. We conducted mobile element insertion (MEI) profiling of 44 epithelial ovarian cancers using exome-sequencing data. We identified a total of 106 MEIs using the Mobster program, 8 of which were novel exonic MEIs.