Optimizing Skin Grafting Using Hair-derived Skin Grafts: The Healing Potential of Hair Follicle Pluripotent Stem Cells

Wounds. 2016 Apr;28(4):109-11.

Abstract

Background: A man in his 60s with recurrent venous leg ulcers (VLUs) presented with an 18-month history of a VLU on his medial left leg measuring 59.3 cm(2). He had been treated with multi- component compression bandages without significant decrease in ulcer size. Given the ulcer's size, refractory nature, and history of recurrence, the authors sought to optimize the patient's healing.

Methods: Approximately 23% of the total wound was treated using punch grafts (PGs) harvested from different locations on the body based on hair density using the "stick and place" method.

Results: One month later, a 56% reduction in ulcer size was observed, especially in the area that received hair-bearing skin.

Conclusion: Punch grafts from hair-bearing skin are a viable source of follicular stem cells and may be superior to PG from nonhair-bearing skin for the treatment of chronic wounds.

Publication types

  • Case Reports

MeSH terms

  • Hair Follicle / transplantation*
  • Humans
  • Leg Ulcer / surgery*
  • Male
  • Pluripotent Stem Cells / transplantation*
  • Skin Transplantation / methods*
  • Transplantation, Autologous / methods
  • Transplants / transplantation*
  • Treatment Outcome
  • Wound Healing*