Objective: To establish a miniature pig model of mandibular osteoradionecrosis (ORN).
Methods: A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.
Results: At 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.
Conclusion: A miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.
目的: 探讨利用小型猪建立下颌骨放射性骨坏死（ORN）动物模型的可行性。
方法: 应用三维适形放疗（3D-CRT）技术，采用电子直线加速器照射源对24只小型猪右侧下颌骨进行25 Gy和28 Gy一次性照射，于照射结束后2个月拔除双侧下颌第一磨牙，通过定期局部观察、X线、CT检查和组织病理学方法诊断下颌骨ORN的发生。
结果: 照射结束后3~4个月，拔牙后的小型猪先后全部发生了下颌骨ORN，28 Gy+拔牙组症状较重。
结论: 25 Gy单一剂量放射小型猪下颌骨+拔牙能建立有效的、可信的下颌骨ORN模型，可用于ORN病因学及治疗等方面的进一步研究。