Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

Adeyinka Aina; Manish Gupta; Yamina Boukari; Andrew Morris; Nashiru Billa; Stephen Doughty

doi:10.1016/j.jsps.2015.03.015

Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

Saudi Pharm J. 2016 Mar;24(2):227-31. doi: 10.1016/j.jsps.2015.03.015. Epub 2015 Mar 21.

Authors

Adeyinka Aina¹, Manish Gupta², Yamina Boukari³, Andrew Morris³, Nashiru Billa³, Stephen Doughty³

Affiliations

¹ Department of Mathematics and Natural Science, American University of Iraq, Kirkuk Main Road, Raparin, Sulaimani, Iraq; Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.
² Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia; School of Pharmacy, Monash University Malaysia Campus, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
³ Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.

Abstract

The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

Keywords: Encapsulation; Model drugs; PLGA; XRPD.