Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1

Pavithra Viswanath; Sabrina M Ronen

doi:10.1080/23723556.2015.1077922

Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1

Mol Cell Oncol. 2016 Apr 1;3(2):e1077922. doi: 10.1080/23723556.2015.1077922. Epub 2015 Aug 27.

Authors

Pavithra Viswanath¹, Sabrina M Ronen¹

Affiliation

¹ Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street San Francisco 94143, CA, USA.

Abstract

Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that the IDH1 mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and reprogramming of pyruvate metabolism is essential for cell proliferation in mutant IDH1 glioma cells.

Keywords: 2-HG; IDH1; gliomas; metabolic reprogramming; pyruvate dehydrogenase.

Abstract

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