Abstract
Various clinical and epidemiologic studies show that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin and cyclooxygenase inhibitors (COXIBs) help prevent cancer. Since eicosanoid metabolism is the main inhibitory targets of these drugs the resulting molecular and biological impact is generally accepted. As our knowledge base and technology progress we are learning that additional targets may be involved. This review attempts to summarize these new developments in the field.
Keywords:
Aspirin; Cancer prevention; Inflammation; Non-steroidal anti-inflammatory drugs (NSAID).
Published by Elsevier Inc.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / metabolism*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Aspirin / metabolism
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Aspirin / pharmacology*
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Aspirin / therapeutic use
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Blood Platelets / drug effects
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Chemoprevention
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Cyclooxygenase Inhibitors / metabolism
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Cyclooxygenase Inhibitors / pharmacology*
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Cyclooxygenase Inhibitors / therapeutic use
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Dinoprostone / metabolism*
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Eicosanoids / antagonists & inhibitors
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Eicosanoids / metabolism
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Glucose / metabolism
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Humans
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Immunity, Cellular / drug effects
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Inflammation / metabolism
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Neoplasms / immunology
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Neoplasms / prevention & control*
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Signal Transduction / drug effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Eicosanoids
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Glucose
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Dinoprostone
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Aspirin