Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage

Lesibana A Malinga; Thomas Abeel; Christopher A Desjardins; Talent C Dlamini; Gail Cassell; Sinéad B Chapman; Bruce W Birren; Ashlee M Earl; Martie van der Walt

doi:10.1128/genomeA.01771-15

Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage

Genome Announc. 2016 Mar 3;4(2):e01771-15. doi: 10.1128/genomeA.01771-15.

Authors

Lesibana A Malinga¹, Thomas Abeel², Christopher A Desjardins³, Talent C Dlamini⁴, Gail Cassell⁵, Sinéad B Chapman³, Bruce W Birren³, Ashlee M Earl³, Martie van der Walt⁶

Affiliations

¹ South African Medical Research Council TB Platform, Pretoria, Gauteng, South Africa Department of Internal Medicine, University of Pretoria, Pretoria, Gauteng, South Africa lesibana.malinga@mrc.ac.za.
² Broad Institute, Cambridge, Massachusetts, USA Delft Bioinformatics Laboratory, Delft University of Technology, Delft, The Netherlands.
³ Broad Institute, Cambridge, Massachusetts, USA.
⁴ Medical Laboratory Sciences Department, Southern Africa Nazarene University, Manzini, Swaziland.
⁵ Harvard Medical School and Infectious Diseases Research Institute, Boston, Massachusetts, USA.
⁶ South African Medical Research Council TB Platform, Pretoria, Gauteng, South Africa.

Abstract

We report the whole-genome sequencing of two extensively drug-resistant tuberculosis strains belonging to the Euro-American S lineage. The RSA 114 strain showed single-nucleotide polymorphisms predicted to have drug efflux activity.

Abstract

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