Multimodal-Imaging-Guided Cancer Phototherapy by Versatile Biomimetic Theranostics with UV and γ-Irradiation Protection

Adv Mater. 2016 May;28(17):3273-9. doi: 10.1002/adma.201505700. Epub 2016 Mar 1.

Abstract

A versatile biomimetic theranostic agent based on magnetic melanin nanoparticles is developed for positron-emission tomography/magnetic resonance/photoacoustic/photothermal multimodal-imaging-guided cancer photothermal therapy and UV and γ-irradiation protection.

Keywords: UV protection; iron oxide; melanin; photoacoustic imaging; photothermal therapy; theranostics; γ protection.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use*
  • Cell Line, Tumor
  • Cell Survival
  • Copper / chemistry
  • Gamma Rays* / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Melanins / chemistry
  • Mice
  • Mice, Nude
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use
  • Nanoparticles / toxicity
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Phototherapy*
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography
  • Radiopharmaceuticals / chemistry
  • Theranostic Nanomedicine*
  • Transplantation, Heterologous
  • Ultraviolet Rays*

Substances

  • Biocompatible Materials
  • Melanins
  • Radiopharmaceuticals
  • Copper