Pathology and Genetics of Pancreatic Neoplasms

Omer H Yilmaz; Vikram Deshpande

doi:10.1016/j.path.2012.08.008

Pathology and Genetics of Pancreatic Neoplasms

Surg Pathol Clin. 2012 Dec;5(4):941-59. doi: 10.1016/j.path.2012.08.008.

Authors

Omer H Yilmaz¹, Vikram Deshpande²

Affiliations

¹ Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Warren 2, Boston, MA 02478, USA.
² Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Warren 2, Boston, MA 02478, USA. Electronic address: vdeshpande@partners.org.

PMID: 26838509
DOI: 10.1016/j.path.2012.08.008

Abstract

This is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. Although understanding of the molecular features underlying pancreatic neoplasms is still in its infancy, a strong emphasis on the relevance of these findings for the practicing surgical pathologist is provided. The application of molecular techniques has yielded a wealth of information that may soon enhance diagnostics, and will also lead to the development of safer, more effective targeted therapies. The pathologist will play a key role in integrating the current pathologic classification system with newly validated molecular markers.