Abstract
A new study shows how a single cytokine, interleukin-4, regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Lineage / genetics
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DNA Methylation / genetics*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Dendritic Cells / cytology
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Dendritic Cells / metabolism
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Dioxygenases
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Epigenomics
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Hematopoiesis / genetics*
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Humans
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Interleukin-4 / genetics*
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Interleukin-4 / metabolism
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Janus Kinase 3 / genetics*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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STAT6 Transcription Factor / genetics*
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Signal Transduction
Substances
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DNA-Binding Proteins
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IL4 protein, human
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Proto-Oncogene Proteins
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STAT6 Transcription Factor
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STAT6 protein, human
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Interleukin-4
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Dioxygenases
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TET2 protein, human
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JAK3 protein, human
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Janus Kinase 3