1 1Division of Pharmacy, Cincinnati Children's Hospital Medical Center 2Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center 3Department of Pediatrics, University of Cincinnati, College of Medicine 4Cancer & Blood Disease Institute, Division of Oncology, Cincinnati Children's Hospital Medical Center 5Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 6Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA.