Genetic imaging consortium for addiction medicine: From neuroimaging to genes

Scott Mackey; Kees-Jan Kan; Bader Chaarani; Nelly Alia-Klein; Albert Batalla; Samantha Brooks; Janna Cousijn; Alain Dagher; Michiel de Ruiter; Sylvane Desrivieres; Sarah W Feldstein Ewing; Rita Z Goldstein; Anna E Goudriaan; Mary M Heitzeg; Kent Hutchison; Chiang-Shan R Li; Edythe D London; Valentina Lorenzetti; Maartje Luijten; Rocio Martin-Santos; Angelica M Morales; Martin P Paulus; Tomas Paus; Godfrey Pearlson; Renée Schluter; Reza Momenan; Lianne Schmaal; Gunter Schumann; Rajita Sinha; Zsuzsika Sjoerds; Dan J Stein; Elliot A Stein; Nadia Solowij; Susan Tapert; Anne Uhlmann; Dick Veltman; Ruth van Holst; Henrik Walter; Margaret J Wright; Murat Yucel; Deborah Yurgelun-Todd; Derrek P Hibar; Neda Jahanshad; Paul M Thompson; David C Glahn; Hugh Garavan; Patricia Conrod

doi:10.1016/bs.pbr.2015.07.026

Genetic imaging consortium for addiction medicine: From neuroimaging to genes

Prog Brain Res. 2016:224:203-23. doi: 10.1016/bs.pbr.2015.07.026. Epub 2015 Nov 4.

Authors

Scott Mackey¹, Kees-Jan Kan², Bader Chaarani², Nelly Alia-Klein³, Albert Batalla⁴, Samantha Brooks⁵, Janna Cousijn⁵, Alain Dagher⁶, Michiel de Ruiter⁷, Sylvane Desrivieres⁸, Sarah W Feldstein Ewing⁹, Rita Z Goldstein³, Anna E Goudriaan¹⁰, Mary M Heitzeg¹¹, Kent Hutchison¹², Chiang-Shan R Li¹³, Edythe D London¹⁴, Valentina Lorenzetti¹⁵, Maartje Luijten¹⁶, Rocio Martin-Santos¹⁷, Angelica M Morales¹⁸, Martin P Paulus¹⁹, Tomas Paus²⁰, Godfrey Pearlson¹³, Renée Schluter²¹, Reza Momenan²², Lianne Schmaal²³, Gunter Schumann⁸, Rajita Sinha¹³, Zsuzsika Sjoerds²⁴, Dan J Stein⁵, Elliot A Stein²⁵, Nadia Solowij²⁶, Susan Tapert²⁷, Anne Uhlmann⁵, Dick Veltman²³, Ruth van Holst²¹, Henrik Walter²⁸, Margaret J Wright²⁹, Murat Yucel¹⁵, Deborah Yurgelun-Todd³⁰, Derrek P Hibar³¹, Neda Jahanshad³¹, Paul M Thompson³¹, David C Glahn¹³, Hugh Garavan², Patricia Conrod³²

Affiliations

¹ Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA. Electronic address: msmackey@uvm.edu.
² Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
³ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Department of Psychiatry and Psychology, Hospital Clínic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain; Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁵ Department of Psychiatry and MRC Unit on Anxiety & Stress Disorders, University of Cape Town, Cape Town, South Africa.
⁶ Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
⁷ Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁸ Institute of Psychiatry, King's College London, London, UK.
⁹ Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
¹⁰ Department of Psychiatry and MRC Unit on Anxiety & Stress Disorders, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
¹² Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
¹³ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
¹⁴ Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
¹⁵ School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences and Monash Biomedical Imaging, Monash University, Melbourne, Australia.
¹⁶ Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
¹⁷ Department of Psychiatry and Psychology, Hospital Clínic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
¹⁸ David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
¹⁹ VA San Diego Healthcare System and Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Laureate Institute for Brain Research, Tulsa, OK, USA.
²⁰ Rotman Research Institute, University of Toronto, Toronto, ON, Canada.
²¹ Department of Psychiatry, University of Amsterdam, Amsterdam, The Netherlands.
²² Section on Brain Electrophysiology and Imaging, Institute on Alcohol Abuse and Alcoholism, Bethesda, USA.
²³ Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
²⁴ Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
²⁵ Intramural Research Program-Neuroimaging Research Branch, National Institute on Drug Abuse, Baltimore, MD, USA.
²⁶ School of Psychology, University of Wollongong, Wollongong, NSW, Australia.
²⁷ Laureate Institute for Brain Research, Tulsa, OK, USA.
²⁸ Department of Psychiatry and Psychotherapy, Charité Universitatsmedizin, Berlin, Germany.
²⁹ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
³⁰ Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
³¹ Department of Neurology, Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
³² Department of Psychiatry, Université de Montreal, CHU Ste Justine Hospital, Montreal, QC, Canada.

Abstract

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.

Keywords: Addiction; ENIGMA; Genetic imaging; Neuroimaging.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Brain / diagnostic imaging*
Genetic Testing
Humans
Meta-Analysis as Topic
Neuroimaging*
Phenotype
Substance-Related Disorders / drug therapy*
Substance-Related Disorders / genetics*

Abstract

Publication types

MeSH terms

Grants and funding